OCTOBER 7-8-9, 2022

Holiday Inn Rome EUR Parco dei Medici

Since 2010 Mitocon organizes the Mitochondrial Diseases Conference, to encourage the exchange of knowledge and experience between doctors and researchers, patients, family members and caregivers, with the participation of the leading Italian and international experts.

Mitochondrial diseases are very complex disorders, still little known by the scientific community, with multi-system manifestations and different ages of onset, ranging from infancy to adulthood. In recent years, giant steps have been taken in the study of the basic mechanisms involved in these diseases and we have finally moved from diagnosis to the study of possible treatments.

Our conference has contributed to this process by gathering the entire community of Italian doctors and researchers around the association of patients and helping to strengthen international partnerships and collaborations, making the whole community grow together and contributing to sharing knowledge and research progress.

The conference is hybrid with both face-to-face and online participation (online participation will be possible only for October 7 and 8). The scientific sessions will be entirely in English to facilitate the participation of doctors and researchers from all over the world, promoting international exchange and collaboration, crucial to fight together against mitochondrial diseases. Simultaneous translation into Italian will be provided.

Mitocon is the Italian leading non-profit mitochondrial diseases patients organization striving to advance research towards finding a cure. Encouraging collaboration and the exchange of knowledge within the scientific community is our priority.

Get in touch with us on mitocon.it

Preliminary scientific programme

Continuing Medical Education – CME credits (10 credits) will be provided only for those who attend in presence.

Simultaneous translation will be provided during the scientific sessions

Plenary room
Day 1: Friday, October 7 

09.00 – 09.30 AM
Arrivals & Registration


09.30 – 10.00 AM
Welcome to the Mitochondrial Diseases Conference 2022

Marco Marmotta
, President, Mitocon – Insieme per lo Studio e la Cura delle Malattie Mitocondriali ODV
Michelangelo Mancuso, Costanza Lamperti, Scientific Committee Delegates
Mito Patients and Families What Does Mitochondrial Disease Mean to Me – Stories/Video


10.00 -10.30 AM
Keynote Lecture:’Manipulating Mitochondrial DNA’

Introduction:
Carlo Viscomi
Speaker:
Mary Herbert


10:30 – 10:50 AM
A new era of mitochondrial genome editing

Speaker:
Jim-Soo Kim
Q&A 


11:00-11:30 AM
Coffee Break


11:30 – 1:00 PM
Session 1: Basic Science

Moderators:
Valeria Tiranti, Piero Santantonio
Speakers:

11:30 Antonella Spinazzola – Mitochondrial DNA disorders: mechanisms and potential therapeutic strategies
11:50 Michela Di Nottia – Free cytosolic-mitochondrial DNA triggers a potent type-I Interferon response in Kearns–Sayre patients counteracted by mofetil mycophenolate
12:10 Andrea Legati – Advantages of short and long-read NGS in the genetic analysis of the mitochondrial DNA
12:30 Luca Scorrano – A screening for compounds that ameliorate mitochondrial function in ADOA
Q&A 


1:00- 2:30 PM
Lunch


2:30 – 4:15 PM
Session 2: Leigh Syndrome Road Map

Moderators:
Philip Yeske, Piero Santantonio
Speakers:
2:30 Introduction: Massimo Zeviani
2:50 SPEAKER TO BE CONFIRMED
3:10 Alessandro Prigione – Induced pluripotent stem cells (iPSC)-driven drug repositioning for Leigh Syndrome
3:25 Roan Louw – Metabolic investigation of Leigh Syndrome – the search for novel treatment options
3:40 Gino Cortopassi – Fumarates rescue multiple mouse models of Mitochondrial disease: Leigh, Friedreich’s, LHON
3:55 Phil Yeske – Patient-Led Research- An Update on the Global Leigh Syndrome Roadmap Project
Q&A


4:15 – 4:45 PM
Coffee Break


4:45 – 5:45 PM
Session 3: Exploring and managing PMD phenotypes

Moderators:
Michelangelo Mancuso, Paola Desideri
Speakers:
4:45 Robert McFarland – Management of stroke like episodes
5:10 Amel Kaara – Approaching a patient with possible PMD: an existential crisis?
Q&A


5:45 – 6:15 PM
Posters and Mitoideas Award 2022 (NO CME)

Moderators:
Costanza Lamperti, Paola Desideri


6:30 PM
End of day 1



Plenary room
Day 2: Saturday October 8 

On Saturday October 8, during the conference, activities for children will be organised in the Properzio Room.

8:30 -9:00
Arrivals & Registration


9:00 -9:20 AM 

Session 4: Progress in clinical research for new treatment options for LHON: an exciting landscape for Patients and Clinicians

Moderators

Valerio Carelli, Paula Morandi

Speaker
Lorena Castillo

9:00 -10:30 AM
Session 5: Challenges and pitfalls in clinical trials design –presentations and round table discussion

Moderators:
Enrico Bertini, Paula Morandi
Speakers:
9:00 SPEAKER TO BE CONFIRMED
9:20 Magali Taiel – Gene Therapy Development in Leber Hereditary Optic Neuropathy
9:30 Livia Tomasso, Medical Advisor Rare Diseases, EU & Emerging Markets Global Rare Disease Business Unit, Chiesi Group
9:40 Madhu Davies, Medical Director, Reneo Pharma Ltd
9:50 Magnus Hansson, Chief Medical Officer, VP preclinical & clinical development, Abliva
10:00 Anthony Abbruscato, Senior Director, Clinical Development, Stealth BioTherapeutics
10:10 Matthew Klein, Chief Operating Officer, PTC Therapeutics
10:20 Speaker TO BE CONFIRMED
Q&A


10:30 -11:00
Coffee Break


10:45 -11:15 PM
Posters and MitoIdeas Awards 2022 (NO CME)

Moderator:
Costanza Lamperti, Paola Desideri


11:30– 12:15 PM
Session 6: Breaking news

Moderator:
Olimpia Musumeci, Piero Santantonio
Speakers:
11:30 Breaking News
11:45 Breaking News
12:00 Breaking News
Q&A


12:30 – 1:30 PM
Session 7: COVID-19 and Long COVID in PMD

Moderator:
Serenella Servidei, Paola Desideri
Speakers:
12:30 Robert Pitceathly – The European Mito COVID Experience. (London, dovrebbe uscire a breve il lavoro europeo covid in PMD su Neurology)
12:50 Massimiliano Filosto – Long-Covid manifestations in Neuromuscular and mitochondrial diseases.
Q&A


1:30
Closing of the scientific part of the congress

Preliminary programme for patients and families

SATURDAY, October 8 

On Saturday October 8, during the conference, activities for children will be organised in the Properzio Room.


Plenary  room

15.30 – 16.00 From clinical diagnosis to genetic diagnosis
16:00 – 16:30 The Diagnostic Therapeutic Assistance Pathways (PDTA) for mitochondrial patients
16:30 – 17:00 Mitochondrial DNA replacement techniques
17:00 – 17:30 Integrating the disease into daily life


Catullo room

15.30 – 17.30 Presentation of tools for blind and visually impaired people by the Typhlo-technical Promotion Center of the Italian Union of the Blind and Visually Impaired in Rome
17.30 – 19.00 Mito-aperitif


Catullo room

18.00 – 19.30 Prof. Valerio Carelli meets patients with mitochondrial diseases affecting eyes


Aristotele room

17.30 – 19.30 Pediatric medical consultations

Dr. Anna Ardissone, IRCCS Foundation Carlo Besta Neurological Institute, Milan
Dr. Enrico Silvio Bertini, IRCCS Bambino Gesù Pediatric Hospital, Rome


Cicerone room

17.30 – 19.30 Adult medical consultations

Prof. Serenella Servidei, Agostino Gemelli University Hospital Foundation IRCCS Catholic University of the Sacred Heart, Rome
Dr. Costanza Lamperti, IRCCS Foundation Carlo Besta Neurological Institute, Milan


Omero room

17.30 – 19.30 Nutrition and genetic diagnosis consultations

Dr. Marzia Giulia Camera, nutritionist biologist
Dr. Andrea Bartuli, IRCCS Bambino Gesù Pediatric Hospital, Rome



SUNDAY October 9 

Plenary  room

10.00 – 10.45 Kick-off message from the scientific conference, Q&A, Serenella Servidei, Agostino Gemelli University Hospital Foundation IRCCS Catholic University of the Sacred Heart, Rome
10.45 – 12.30 Presentation of Mitocon ODV activities

  • Anthony Abbruscato, Senior Director, Clinical Development, Stealth BioTherapeutics
  • Andrea Bartuli Head of the Complex Operative Unit Rare Diseases and Medical Genetics Children’s Hospital Bambino Gesù
  • Enrico Bertini, Neuromuscular and Neurodegenerative Disorders, Bambino Gesù Children’s Research Hospital, Rome
  • Anna Ardissone, Metabolic, Degenerative and Neuromuscular Diseases, Child Neurology Unit – Department of Pediatric Neuroscience Mariani Foundation center for Mitochondrial Pediatric disease study
    IRCCS Foundation Neurological Institute Carlo Besta
  • Valerio Carelli, IRCCS Institute of Neurological Sciences (ISNB), Bellaria Hospital, University of Bologna
  • Lorena Castillo, Head of the Neuro-Ophthalmology Department at the ICR Ophthalmology Center
  • Gino Cortopassi, Professor Molecular Biosciences, University of California
  • Madhu Davies, Medical Director, Reneo Pharma Ltd
  • Paola Desideri, Vice President Mitocon
  • Michela Di Nottia, Researcher Neuroscience, Bambino Gesù Children’s Hospital
  • Massimiliano Filosto, NeMO Clinical Center-Brescia for Neuromuscolar Diseases; Department of Clinical and Experimental Sciences, University of Brescia
  • Magnus Hansson, Chief Medical Officer, VP preclinical & clinical development, Abliva
  • Mary Herbert Professor of Reproductive Biology, Newcastle Fertility Centre International Centre for Life
  • Amel Kaara, M.D., Massachusetts General Hospital
  • Jin- Soo Kim Director Center for Genome Engineering, Institute for Basic Science, Republic of Korea
  • Matthew Klein, Chief Operating Officer, PTC Therapeutics
  • Costanza Lamperti, Division of Medical Genetics and Neurogenetics, Mariani Foundation Center for the Study of Mitochondrial Pediatric Diseases, Foundation IRCCS Neurological Institute “C. Besta”, Milan
  • Andrea Legati PhD, The Foundation of the Carlo Besta Neurological Institute | IRCCS · Unit of Medical Genetics and Neurogenetics
  • Roan Louw, Research Director, Human Metabolomics at North-West University, Noordwes-Universiteit
  • Michelangelo Mancuso, AOUP, Neurological Institute, University of Pisa
  • Marco MarmottaPresident, Mitocon
  • Robert McFarland Professor of Paediatric Mitochondrial Medicine and Hon Consultant Paediatric Neurologist, Wellcome Centre Mitochondrial Research, New Castle University
  • Paula Morandi, Patients’ Representative for Mitochondrial Eye DiseasesMember of Mitocon, IMP Board Member
  • Olimpia Musumeci, AOU Policlinico “G.Martino”, University of Messina
  • Robert Pitceathly, Principal Research Fellow Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology
  • Alessandro Prigione, Group Leader Stem Cell Metabolism, Department of General Pediatrics, University Children’s Hospital, Heinrich-Heine-University, Düsseldorf
  • Piero Santantonio, Founder Mitocon
  • Serenella Servidei, Neurology Institute, Catholic University of the Sacred Heart, Rome
  • Luca Scorrano, Professor of Biochemistry Dept. of Biology, University of Padova and VIMM
  • Antonella Spinazzola, Professor PI, Neuroscience and Mitochondrial Medicine Brain Research UK Miriam Marks Senior Fellow UCL Queen Square Institute of Neurology, Royal Free Campus, London
  • Magali Taiel, Chief Medical Officer, Gensight-Biologics
  • Valeria Tiranti, Division of Medical Genetics and Neurogenetics,
  • Mariani Foundation Center for the Study of Mitochondrial Pediatric Diseases, Foundation IRCCS Neurological Institute “C. Besta”, Milan
  • Livia Tomasso, Livia Tomasso. Medical Advisor Rare Diseases, EU & Emerging Markets Global Rare Disease Business Unit, Chiesi Group
  • Carlo Fiore Viscomi, Department of Biomedical Sciences, University of Padova
  • Philip Yeske, PhD Science & Alliance Officer, United Mitochondrial Disease Foundation
  • Massimo Zeviani, Scientific Director IRCCS Burlo Garofolo, Professor of Neurology, Human Physiology, General Pathology
  • Enrico Bertini, Neuromuscular and Neurodegenerative Disorders, Bambino Gesù Children’s Research Hospital, Rome.
  • Valerio Carelli, IRCCS Institute of Neurological Sciences (ISNB), Bellaria Hospital, Bologna/University of Bologna.
  • Massimiliano Filosto, NeMO Clinical Center-Brescia for Neuromuscolar Diseases; Department of Clinical and Experimental Sciences, University of Brescia.
  • Costanza Lamperti, Division of Medical Genetics and Neurogenetics, Mariani Foundation Center for the Study of Mitochondrial Pediatric Diseases, Foundation IRCCS Neurological Institute “C. Besta”, Milan.
  • Michelangelo Mancuso, AOUP, Neurological Institute, University of Pisa.
  • Olimpia Musumeci, AOU Policlinico “G.Martino”, University of Messina.
  • Serenella Servidei, Neurology Institute, Catholic University of the Sacred Heart, Rome.
  • Valeria Tiranti, Division of Medical Genetics and Neurogenetics, Mariani Foundation Center for the Study of Mitochondrial Pediatric Diseases, Foundation IRCCS Neurological Institute “C. Besta”, Milan.
  • Carlo Fiore Viscomi, Department of Biomedical Sciences, University of Padova.

To participate in the conference, both face-to-face and online, you need to register. Registration is subject to the payment of a registration fee. Registration is free for patients, family members and caregivers.

FACE TO FACE REGISTRATION

Patients, family members, caregivers
Registration is free for patients, family members and caregivers. The following are subject to charges: accommodation, meals, parking space in the hotel car park. Consultations with doctors, free of charge, must be booked and they are subject to availability.
The deadline for registration is Monday 26.09.2022.

Mitocon will reimburse travel expenses, according to the following limits:

  • <150 km no refund
  • km150- 300 € 20
  • km300-500 € 50
  • km> 500 € 80

Refunds are intended per family unit. To request reimbursement, at the end of the conference and in any case no later than October, an e-mail must be sent to segreteria@mitocon.it indicating: name and surname, IBAN, amount and nature of the expense (eg. train, plane, own vehicle), attaching the supporting documents (e.g. tickets, payment receipts).

Healthcare personnel and other professions with ECM

Registration fee:

  • By31/08/2022: € 150
  • By 09/26/2022: € 260

Registration includes the conference material, coffee breaks and the CME certificate. The following must be paid separately: accommodation, meals, parking space in the hotel car park.
The deadline for registration is Monday 26.09.2022.

Only the first 100 will be accepted. CME credits will be granted to registered attendees based upon attendance of 100% of the scientific sessions and completion of the final evaluation questionnaire.

Healthcare personnel and other professions without CME

Registration fee:

  • By 31/08/2022: € 120
  • By 09/26/2022: € 230

The following must be paid separately: accommodation, meals, parking space in the hotel car park.
The deadline for registration is Monday 26.09.2022.

Students with ECM

Registration fee:

  • By 31/08/2022: € 80
  • By 09/26/2022: € 160

Registration includes the conference material, coffee breaks and the CME certificate. The following must be paid separately: accommodation, meals, parking space in the hotel car park.
The deadline for registration is Monday 26.09.2022.

Only the first 100 will be accepted. CME credits will be granted to registered attendees based upon attendance of 100% of the scientific sessions and completion of the final evaluation questionnaire.

Students without ECM

Registration fee:

  • By 31/08/2022: € 70
  • By 09/26/2022: € 140

The following must be paid separately: accommodation, meals, parking space in the hotel car park.
The deadline for registration is Monday 26.09.2022.


ONLINE REGISTRATION

Patients, family members, caregivers
Registration is free for patients, family members and caregivers. After completing the registration form, you will receive an e-mail with the link to access the online conference.
It is possible to register at any time, even during the conference.

Healthcare personnel, other professions, students
Registration is subject to the payment of a registration fee of € 40. After completing the registration form, you will receive an e-mail with instructions to pay the registration fee and complete the registration.
The deadline for registration is Monday 3 October 2022.

 REGISTRATION IS NOW OPEN!

Join us for the Mitochondrial Disease Conference from 7th to 9th October.
Select how to attend

Holiday Inn Rome EUR Parco dei Medici

Everybody is welcome to attend. Registration is subject to the payment of a registration fee. Registration is free for patients, family members and caregivers. Accommodation, meals, parking space must be paid separately.

Click on the box below to register.

MDC 2022
Patients, family members,
caregivers

MDC 2022
Health personnel, other professions with CME credits

MDC 2022
Health personnel, other professions without CME credits

MDC 2022
Students with CME credits

MDC 2022
Students without CME credits

Everybody who cannot join us in Rome is welcome to attend online. Registration is subject to the payment of a registration fee. Registration is free for patients, family members and caregivers.

CME credits will not be available for online attendees.

Click on the box below to register.

MDC 2022
Patients, family members, caregivers

MDC 2022
Health personnel, other professions, students

Your generosity will help Mitocon supporting the participation of patients and families by keeping registration free of charge and reducing costs for accommodation and meals.

Stay with Us. You can make a difference in the lives of those affected by a mitochondrial disease.
Thank you!

With the patronage of